MyBioSource.com's HDAC5 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunofluorescence, Immunohistochemistry, and Western Blot. The HDAC5 Antibody was generated using HDAC5 as the antigen and it reacts with Human, Mouse, and Rat.
Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors.Claudie Lemercier, J. Biol. Chem., May 2000; 275: 15594.Carmen C. Sucharov, Am J Physiol Cell Physiol, Nov 2006; 291: C1029 - C1037.Michael P. Czubryt, PNAS, Feb 2003; 100: 1711.changhoon ha, FASEB J, Apr 2007; 21: A528